Innovation
R&D Breakthrough
Amorphical has developed a unique technology for industrially synthesizing several nanoparticle amorphous minerals based on biomimicry while acquiring in-depth knowledge of the features and benefits inherent to the gastrolith of the blue crab. This unique, patent-protected technology enables the stabilization of several essential minerals in an amorphous physical structure while maintaining their nanometric particle size. Amorphous solid dispersions based on nanosized particles are an established method of increasing compounds’ permeability, bioavailability, and biological activity.
Due to the unique capabilities of Amorphical’s active ingredients and depending on the different forms of administration, Amorphical can treat a wide variety of diseases, some in the bone area and some in the area of inflammatory diseases such as osteoporosis, osteoporotic fractures, hypoparathyroidism, solid tumors, osteoarthritis, COPD, Crohn’s disease and other inflammatory diseases.
ACC uniqueness
Amorphical has recognized the wide and unusual medical potential of ACC, and successfully made it suitable for human consumption after years of research and development.
Clinical and preclinical trials demonstrated that the absorption of ACC is at least twice better (on average) than crystalline calcium carbonate and significantly better than calcium citrate (which are the two main active ingredients in commercially available calcium supplements). The calcium supplied by ACC was found to have a significantly higher bioavailability and bioactivity than other available calcium supplement, including unprecedented functionalities.
The connection between Amorphical’s material, ACC (Amorphous Calcium Carbonate), and inflammation is centered around the role of local acidic microenvironments, which are common in many inflammatory diseases and cancerous tumors. Inflammatory processes lead to a drop in tissue pH, causing local acidification. This acidification impairs immune cell function and activates inflammatory agents such as cytokines, proteases, and osteoclasts.
ACC, due to its unique chemical properties, becomes soluble and active under acidic conditions, where it helps normalize local pH by releasing carbonate ions. These ions buffer excess protons, restoring a balanced pH and reducing inflammation. Amorphical’s preclinical studies have shown that ACC can decrease inflammatory responses and inhibit tumor progression by normalizing pH levels in affected tissues.
Thus, ACC’s ability to target acidic microenvironments makes it a promising agent for treating a range of inflammatory diseases and conditions.
Patents
Amorphical has filed 188 patent applications: 125 patents were already approved in different countries and 63 are in various examination stages registration process, worldwide.
The main patent families, designated for treating various medical conditions, cover:
- Treatment of Cancer, Pain, Neurological Disorders, Alzheimer’s Disease and Dementia and other inflammatory diseases
- Osteoporosis, Osteopenia, Hypocalcemia and Hypoparathyroidism
- Muscular Dystrophy, IVF and Sperm Quality
- Muscle Inflammations and Bone Injuries, caused by Repetitive Stress
Osteoporosis & Calcium
Bone loss is a natural process that accelerates over the age of 40 and may cause osteoporosis, fractures and other health issues. The prevalence of osteoporosis has been significantly rising and will further expand according to the International Osteoporosis Foundation, due to the worldwide aging of the population and ever-changing lifestyle habits. Simultaneously, there is a rise in both the prevalence and incidence of related fragility fractures. Globally, it is estimated that 1 in 3 women and 1 in 5 men over the age of 50 will experience osteoporosis fractures. It is assessed that the worldwide number of patients with osteoporotic hip fractures is more than 200 million. In both Europe and the United States, 30% of all women are osteoporotic, and it is estimated that 40% post-menopausal women and 30% men will experience an osteoporotic fracture.
Aside its essential role in healthy bones and teeth, calcium is critical for numerous other physiological processes and body systems – cardiovascular, neurological, etc. Calcium deficiency is not immediately noticeable and typically is not detected by routine blood tests. As necessary, our body maintains the required blood’s calcium levels by decomposing bone tissues, which may cause severe and potentially life-threatening health problems.
Commercially available calcium supplements are not efficient enough for achieving appropriate absorption and utilization of calcium. Our body’s ability to absorb the calcium from those products is limited and depends on the supplement’s ability to break down into calcium ions in our stomach, which are then absorbed into the blood through the intestine’s mucous membrane.