Inflammations

Causes for Inflammations

Inflammation is the response of the immune system to pathogenic infections, injuries, certain toxins, and other abnormal conditions. Most inflammations are acute, while others are chronic, driven by either chronic conditions or autoimmune chronic diseases. Inflammations are typically accompanied by hypoxia (low oxygen levels) in the inflamed tissue.  Hypoxia causes a cascade of events leading to acidosis (an acidic environment having a reduction in pH value from physiological pH) in the inflamed tissue. The acidosis increases the severity of the diseases and their symptoms, such as pains and high fever, and reduces the effectiveness of the immune system.

How Can ACC Affect Inflammations?

Modulation of the acidosis would enhance curative effects, including better differentiation and performance of immune cells in healing the inflamed tissue. Amorphous Calcium Carbonate (ACC) exhibits a unique capability to modulate physiological acidic conditions due to its nanometric structure and its controlled dissolution in mild acidic conditions. ACC serves as an acid-neutralizing agent due to its release of basic carbonate ions.

Growing Evidence for ACC efficacy

Preclinical studies have demonstrated that stabilized ACC can effectively abate inflammatory conditions and reduce associated pains in various inflammatory conditions. Such efficacy was observed in a preclinical study with a multiple sclerosis model. Horses suffering from persistent internal bone cysts were healed by oral administration of ACC; there are no standard-of-care medications for curing such cysts. Top professional athletes have been quickly recovered from long-lasting inflammatory bone and muscle pains, resumed intensive training, and even broke their personal and national records. Encouraged by these observations, Amorphical pursues further preclinical and clinical evidence for ACC’s efficacy in treating a variety of inflammatory conditions.