Clinical trials

Improving Top Athletes` Performance

Improving top athletes’ performance is a critical issue that has been extensively studied.
Many methods have been developed to achieve this goal. One option to improve athlete’s
performance is the consumption of nutritional and performance-enhancing ergogenic
supplements. Nutritional supplements are classified according to their degree of
effectiveness in performance improvement.


There are available supplements that contribute to improving performance by reversing
acidosis activities (increasing the blood pH) associated with intense sport activity that leads
to extensive need to generate ATP and causes enhanced release of CO2, both result in
increased the H+ concentration. Two supplements are commonly used to achieve
performance improvement by blood’s pH modulation: (a) sodium bicarbonate (NaHCO3),
which is an extracellular buffer; and (2) beta alanine (β-ALA), which increases the content of
the di-peptide carnosine inside the muscle cells (intracellularly), thus lowering the internal
acidity of cells. A combination of both supplements, compared to the consumption of each
of them alone was found to be more effective for enhanced performance. It is important to
realize that taking the high recommended doses of NaHCO3 recommended to athletes has
undesired side effects, such as nausea and unpleasant feeling in the gastrointestinal tract. It
also significantly increases the undesired consumption of sodium. The use of β-ALA requires
administration of the supplement for a long period to affect the performance and its efficacy
has been scientifically challanged.


Amorphical’s ACC is an excellent candidate to serve as a solid pH buffer (modulator) for
improving athletic performance. It has the potential to improve performance and accelerate
recovery from physical exertion. ACC has already found to be beneficial for top Israeli
athletes that had suffered bone and muscle injuries and chronic inflammations. They have
also reported rapid return to intense practices, followed by personal record breaking.
A designed study is currently performed with an aim to examine the effect ACC, sublingually
administered several days prior to performing the globally-recognized Wingate Test (WAnT),
in which the following variables are measured: maximum and average power, fatigue index,
and recovery from the short but intense cycling effort. The latter assessment includes
measuring the rate (kinetics) of clearing the high levels of lactate in the blood, generated
during the intense exercise.


1. “Examination of Amorphous Calcium Carbonate on the Inflammatory and

     Muscle Damage Response in Experienced Resistance Trained Individuals
     Jay R. Hoffman , Tavor Ben-Zeev, Amit Zamir , Chagai Levi and Ishay Ostfeld


2. “The Effects of Amorphous Calcium Carbonate (ACC) Supplementation on
     Resistance Exercise Performance in Women”
     Yitzhak Weinstein , Yarden Ovadia , Bar Weinstein and Ayelet Weinstein

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