Pre-Clinical Trials

Bone Mass Building, Preservation and pH Regulation

In this group of preclinical studies, we compared between ACC (amorphous calcium carbonate) and CCC (crystalline calcium carbonate, the most widely marketed calcium supplement worldwide) in terms of bone mass building and preservation.

The studies, which focused mainly on chemical traits and characterization, measured and compared between the chemical and biological activity of ACC and CCC using a number of parameters: solubility, pH regulation, bioavailability, and specific calcium pathways from the supplement into the actual bones.

In addition, we conducted studies on fracture and bone cyst healing in horses, and found that ACC helped cure cysts and fractures in sport horses, suffering for a long time and designated for euthanasia.

These studies prove the superiority of ACC over CCC in bone building, preservation and healing.

 

Metabolic Bone Disorder and Osteoporosis Prevention

This study focused on preventing bone loss in rats. The study population included 101 female rats aged 16-17 weeks.

Study findings:

1. Treatment with ACC leads to a greater increase in the femoral bone mass density compared to treatments with CCC and calcium citrate–the most common calcium supplements commercially available today.

2. ACC helps prevent decrease in vertebral mechanical strength, and even increase it.

As far as we know, such high levels of efficacy in preventing bone loss by calcium supplements have never been reported. These findings indicate ACC’s great potential for preventing metabolic bone disorders and osteoporosis.1,2

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